António J. Bastos Leite, M.D., Ph.D., Habil., Neuroradiologist
Assistant Professor of Radiology and Medical Imaging
University of Porto, Faculty of Medicine
Alameda do Professor Hernâni Monteiro
4200-319 Porto, Portugal
ORCID 0000-0001-9672-0202

Research focus:

Neuroimaging in mental disorders, cognitive impairment, and brain ageing

Selected research projects:

  • Brain connectivity in obsessive-compulsive disorder: a functional magnetic resonance imaging study (2012–present)
  • Neuroimaging in anorexia nervosa: brain volume changes as a marker of disease severity (2009–present)
  • Brain connectivity in first-episode schizophrenia: a functional magnetic resonance imaging study (2009–present)

Participation in transnational projects:

Computer-Aided Diagnosis of Dementia based on structural MRI data  (2013-present)

European Cooperation in Science and Technology (COST) Action BM1103: “Arterial Spin Labelling Initiative in Dementia (AID)” (2011-2015)

Vascular Impairment of Cognition Classification Consensus Study (2011-present)

Collaboration with international research groups:

• Dementia Research Centre, University College London, Institute of Neurology, Queen Square, London, United Kingdom (2011–present)

• Wellcome Trust Centre for Neuroimaging, University College London, Institute of Neurology, Queen Square, London, United Kingdom (2011–present)

Selected publications:

Gouveia-Freitas K, Bastos-Leite AJ. Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology. Neuroradiology 2021; 63(10):1581–1597

Santos M, Osório E, Finnegan S, Clarkson M, Timóteo S, Brandão I, Roma-Torres A, Fox NC, Bastos-Leite AJ. Registration-based methods applied to serial high-resolution T1-weighted magnetic resonance imaging for the assessment of brain volume changes in anorexia nervosa of the restricting type. Psychiatry Research: Neuroimaging 2018; 279(30 September):14-18

Bastos-Leite AJ, Ridgway GR, Silveira C, Norton A, Reis S, Friston KJ. Dysconnectivity within the default mode in first-episode schizophrenia: a stochastic dynamic causal modeling study with functional magnetic resonance imaging. Schizophrenia Bulletin 2015; 41(1):144-153

Silveira C, Marques-Teixeira J, de Bastos-Leite AJ. More than one century of schizophrenia: an evolving perspective. The Journal of Nervous and Mental Disease 2012; 200(12):1054-1057

Barkhof F, Fox NC, Bastos-Leite AJ, Scheltens P. Neuroimaging in dementia. 1st ed. Berlin: Springer; 2011

Pedrosa R, Teixeira-Sousa V, Fonseca S, Bastos-Leite AJ. Early-onset Alzheimer disease: the contribution of neuroimaging for the diagnosis. Psychiatry Research: Neuroimaging 2010; 182(3):287-288

Bastos-Leite AJ, Scheltens P. MRI and the differential diagnosis of dementia. In: Jagust W, D’Esposito M, editors. Imaging the aging brain. New York: Oxford University Press; 2009:261-271

Bastos-Leite AJ, Kuijer JP, Rombouts SA, Sanz-Arigita E, van Straaten EC, Gouw AA, van der Flier WM, Scheltens P, Barkhof F. Cerebral blood flow by using pulsed arterial spin-labeling in elderly subjects with white matter hyperintensities. AJNR. American Journal of Neuroradiology 2008; 29(7):1296-1301