Principal Investigator:

António J. Bastos Leite, M.D., Ph.D., Habil., Neuroradiologist
Assistant Professor of Radiology and Medical Imaging
University of Porto, Faculty of Medicine
Department of Medical Imaging
Alameda do Professor Hernâni Monteiro
4200-319 Porto, Portugal
ORCID 0000-0001-9672-0202

Research focus:

Neuroimaging in mental disorders, cognitive impairment, and brain ageing

Selected Research Projects:

  • Brain connectivity in obsessive-compulsive disorder: a functional magnetic resonance imaging study (2012-present)
  • Neuroimaging in anorexia nervosa: brain volume changes as a marker of disease severity (2009-present)
  • Brain connectivity in first-episode schizophrenia: a functional magnetic resonance imaging study (2009-present)

Participation in Transnational Projects:

Computer-Aided Diagnosis of Dementia based on structural MRI data  (2013-present)

European Cooperation in Science and Technology (COST) Action BM1103: “Arterial Spin Labelling Initiative in Dementia (AID)” (2012-2015)

Vascular Impairment of Cognition Classification Consensus Study (2011-present)

Collaboration with external research groups:

Dementia Research Centre – UCL

Selected publications:

Santos M, Osório E, Finnegan S, Clarkson M, Timóteo S, Brandão I, Roma-Torres A, Fox NC, Bastos-Leite AJ. Registration-based methods applied to serial high-resolution T1-weighted magnetic resonance imaging for the assessment of brain volume changes in anorexia nervosa of the restricting type. Psychiatry Research: Neuroimaging 2018; 279(30 September):14-18

Bastos-Leite AJ, Ridgway GR, Silveira C, Norton A, Reis S, Friston KJ. Dysconnectivity within the default mode in first-episode schizophrenia: a stochastic dynamic causal modeling study with functional magnetic resonance imaging. Schizophrenia Bulletin 2015;41(1):144-153

Silveira C, Marques-Teixeira J, de Bastos-Leite AJ. More than one century of schizophrenia: an evolving perspective. The Journal of Nervous and Mental Disease 2012; 200(12):1054-1057

Barkhof F, Fox NC, Bastos-Leite AJ, Scheltens P. Neuroimaging in dementia. 1st ed. Berlin: Springer; 2011

Pedrosa R, Teixeira-Sousa V, Fonseca S, Bastos-Leite AJ. Early-onset Alzheimer disease: the contribution of neuroimaging for the diagnosis. Psychiatry Research: Neuroimaging 2010; 182(3):287-288

Bastos-Leite AJ, Scheltens P. MRI and the differential diagnosis of dementia. In: Jagust W, D’Esposito M, editors. Imaging the aging brain. New York: Oxford University Press; 2009:261-271

Bastos-Leite AJ, Kuijer JP, Rombouts SA, Sanz-Arigita E, van Straaten EC, Gouw AA, van der Flier WM, Scheltens P, Barkhof F. Cerebral blood flow by using pulsed arterial spin-labeling in elderly subjects with white matter hyperintensities. AJNR. American Journal of Neuroradiology 2008; 29(7):1296-1301